LONGEVITY
SCIENCE
Aging is the progressive deterioration of an individual’s physiological integrity (López-Otín et al., 2013) associated with ten major hallmarks. The accumulation of molecular and cellular damage throughout the individual’s lifespan leads to a decline in life quality and aging-related diseases.
Our goal is to uncover mechanisms of aging and prevent or reverse each of the hallmarks of aging through scientific interventions, so that we may live as life intended.
GENESIS-01, TRANSFORMING AGING
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Reduce Biological Age;
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Improve Cellular Function;
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Younger and Better Skin, Body and Mind.
Behavioral Intervention
Digital Platform: Nèctar App
The Nèctar App is a personalized mobile platform built for proactive and precision longevity care. The App helps users to understand and optimize biomarkers using science and science-related tools.
Biological Testing
Diagnostic Kits
Sets of diagnostic kits and services enable users to monitor changes in the DNA, serum biomarkers, microbiome, and more.
Topical Intevention
Cosmeceutical
Nèctar offers a collection of premium topical products created with clinically validated ingredients and formulations that address the molecular changes associated with aging.
Nutritional Intevention
Nutraceutical
Nèctar offers a collection of premium oral supplement products created with clinically validated ingredients and formulations that address the molecular changes associated with aging.
PRODUCTS POWERED BY GENESIS-01
Numerous in vitro and in vivo studies have shown that lifespan and healthspan can be greatly extended by adopting various interventions.
As an interdisciplinary company, Nèctar leverages leading technology, the Genesis-01, to create best-in-class solutions targeting the hallmarks of aging.
Research Partners
What is the Genesis-01
THE GENESIS-01 IS NÈCTAR’S PROPRIETARY TECHNOLOGY BACKED BY ADVANCED A.I. ALGORITHM AND OVER 80 YEARS OF RESEARCH IN LONGEVITY SCIENCE.
01
PHYSIOLOGICAL AGING
Hormonal imbalances, poor lifestyle habits, increased senescent burden and many more factors cause damages to our body. Those cellular damages creates chronic inflammation which increases production and circulation of cytotoxic factors, in turn causes more damage and dysfunction to healthy cells and tissues. It also changes the tissue microenvironment and disturbs signaling in the stem cell niche, inhibiting the proliferation of stem cells and stifling their regenerative capacity. In addition, repair of the cellular damages is an extremely energy demanding processes that depriving other cells’ ability for signalling and epigenetic maintenance.
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ENVIRONMENTAL AGING
Aging is accelerated from exposure to environmental factors such as pollution, UV light and Reactive oxygen species (ROS). The ROS is harmless or even beneficial at a controllable level especially when we are younger. However, our defenses against oxidative stress decreases as we grow older. As the ROS accumulates, it causes damages to mitochondria and other organelles, as well as increases the number of mutations in our DNA.
DRIVERS OF AGING
Across the lifespan, our human body accumulates damages from physiological and environmental factors which leads to cellular dysfunction and eventual aging phenotypes.
AGING PHENOTYPES
SKIN AGING
Skin wrinkles, pigmentation, unbalanced moisture content, unbalanced oil content, and increase in skin sensitivity
BRAIN AGING
Progressive deline in learning, memory, cognitive ability and increased vulnerability to neurodegenerative diseases
NUTRITION DECLINE
Increase in nutrition requirements to maintain physical integrity while suffering from decline in digestive system
HEALTH DECLINE
Aging is the major risk factor for developing most major chronic diseases.
SLEEP DECLINE
Sleep quality and duration of sleep declines at people ages.
PHYSICAL AGING
Rigid bone and muscles loss with age, even with regular exercise
What is inside of the Genesis-01
THE GENESIS-01 COMPRISES OF BIOACTIVE PEPTIDES AND PHYTOCHEMICALS THAT NOT ONLY REVITALIZE AESTHETIC APPEARANCE OF THE SKIN, BUT ALSO REWIND THE CLOCK OF AGING AT A CELLULAR LEVEL.
Genomic Instability
As we age, chromosomes in our cell become less stable and the DNA accumulates damage and mutation. The repair mechanisms also start to fall.
Telomere Attrition
The telomeres at the ends of our chromosomes shorten with each round of cell division, causing cells to stop functioning properly.
Disrupted Proteostasis
The old cells in our body are constantly regraded through autophagy. When these autophagic processes start to fail, damaged and misfolded proteins accumulate in the cell.
Epigenetic Alterations
As cells are exposed to environmental factors, our genes accumulate epigenetic alterations over time which underlie aging-related issues.
Mitochondrial Dysfunction
Mitochondria in our cells are used to convert nutrients into energy. With age, mitochondria accrue mutation and epigenetic changes, leading to cellular dysfunction and aging.
Deregulated Nutrient Sensing
High metabolic activities stress our cells and cause dysfunction as we age.
Senescence
Senescence cells are “zombie” cells that stack up in our body, damaging neighboring cells by secreting pro-inflammatory.
Altered Intercellular Communication
As cells age, they show an increase in self-preserving signals as opposed to adequate chemical communication with their neighbors.
Stem Cell Exhaustion
With age, stem cells of multiple tissues decline in number and lose the ability to differentiate and replace cells throughout the body.
Microbiome Changes
A dysregulated microbiome affect the aging process by contributing to chronic inflammation.
PRIMARY HALLMARKS
HALLMARKS OF AGING
ANTAGONISTIC HALLMARKS
INTEGRATIVE HALLMARKS
WHY DO WE PRIORITIZE NONPHARMACOLOGICAL INTERVENTION?
The foundation of modern health care is built upon a flawed system of “sick-care” or merely prolong the end-of-life period (Tamar Tchkonia, 2020) through expensive yet often ineffective pharmacological means. However, Nèctar Biotech believes the only way to achieve healthy aging is through aging prevention and continuous optimization.
Besides being the more accessible option, behavioral, topical and nutritional interventions have the benefit of influencing all cellular functions without overwhelming any individual pathway in isolation.
We believe such benefits build a solid foundation for further interventions which allow external biochemical compounds to reach their intended optimum result.
